Targeting Cancer with Phytochemicals via Their Fine Tuning of the Cell Survival Signaling Pathways

作者: Salvatore Chirumbolo , Geir Bjørklund , Roman Lysiuk , Antonio Vella , Larysa Lenchyk

DOI: 10.3390/IJMS19113568

关键词: Mechanism (biology)Cancer researchSignal transductionReactive oxygen speciesCancerBiologyCell survivalMitochondrionCellCancer cell lines

摘要: … but can induce tumor cells necroptosis, besides apoptosis [36,37]. … Flavonoids might act in the crosstalk leading to the … reduce the amount of synthetic nutraceuticals and instead promote …

参考文章(207)
Lauren E. Tebay, Holly Robertson, Stephen T. Durant, Steven R. Vitale, Trevor M. Penning, Albena T. Dinkova-Kostova, John D. Hayes, Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease Free Radical Biology and Medicine. ,vol. 88, pp. 108- 146 ,(2015) , 10.1016/J.FREERADBIOMED.2015.06.021
Christian Busch, Markus Burkard, Christian Leischner, Ulrich M. Lauer, Jan Frank, Sascha Venturelli, Epigenetic activities of flavonoids in the prevention and treatment of cancer Clinical Epigenetics. ,vol. 7, pp. 64- 64 ,(2015) , 10.1186/S13148-015-0095-Z
Feifan Zhou, Ying Yang, Da Xing, Bcl-2 and Bcl-xL play important roles in the crosstalk between autophagy and apoptosis FEBS Journal. ,vol. 278, pp. 403- 413 ,(2011) , 10.1111/J.1742-4658.2010.07965.X
Juliet Goldsmith, Beth Levine, Jayanta Debnath, Autophagy and Cancer Metabolism Methods in Enzymology. ,vol. 542, pp. 25- 57 ,(2014) , 10.1016/B978-0-12-416618-9.00002-9
Jiong Yang, Shukun Yao, JNK-Bcl-2/Bcl-xL-Bax/Bak Pathway Mediates the Crosstalk between Matrine-Induced Autophagy and Apoptosis via Interplay with Beclin 1 International Journal of Molecular Sciences. ,vol. 16, pp. 25744- 25758 ,(2015) , 10.3390/IJMS161025744
A Dreiseitel, B Oosterhuis, KV Vukman, P Schreier, A Oehme, S Locher, G Hajak, PG Sand, Berry anthocyanins and anthocyanidins exhibit distinct affinities for the efflux transporters BCRP and MDR1 British Journal of Pharmacology. ,vol. 158, pp. 1942- 1950 ,(2009) , 10.1111/J.1476-5381.2009.00495.X
YONGGEN ZOU, JIEXIANG YANG, DIANMING JIANG, Resveratrol inhibits canonical Wnt signaling in human MG-63 osteosarcoma cells Molecular Medicine Reports. ,vol. 12, pp. 7221- 7226 ,(2015) , 10.3892/MMR.2015.4338
Jingju Pan, Qingshan Chang, Xin Wang, Youngok Son, Zhuo Zhang, Gang Chen, Jia Luo, Yongyi Bi, Fei Chen, Xianglin Shi, Reactive Oxygen Species-Activated Akt/ASK1/p38 Signaling Pathway in Nickel Compound-Induced Apoptosis in BEAS 2B Cells Chemical Research in Toxicology. ,vol. 23, pp. 568- 577 ,(2010) , 10.1021/TX9003193
Irfan Ahmad Mir, Ashu Bhan Tiku, Chemopreventive and therapeutic potential of "naringenin," a flavanone present in citrus fruits. Nutrition and Cancer. ,vol. 67, pp. 27- 42 ,(2015) , 10.1080/01635581.2015.976320