Intracerebroventricular injection of prostaglandin E2 induces thermal hyperalgesia in rats: the possible involvement of EP3 receptors
作者： Takakazu Oka , Shuji Aou , Tetsuro Hori
DOI: 10.1016/0006-8993(94)91275-0
关键词: Central nervous system 、 Prostaglandin E2 、 Chemistry 、 Agonist 、 Prostanoid 、 Endocrinology 、 Internal medicine 、 Hyperalgesia 、 Nociception 、 Receptor 、 Prostaglandin E
摘要: Abstract To determine what types of prostanoid receptors are involved in the central effect prostaglandin E 2 (PGE ) on nociception, we administered PGE and its agonists, i.e., 17-phenyl-ω-trinor (an EP 1 receptor agonist), butaprost agonists), 11-deoxy /EP 3 agonist, ⪢ M&B28767 agonist) into lateral cerebroventricle (LCV) rats observed changes paw-withdrawal latency a hot plate. The LCV injection (10 pg/kg-10 ng/kg), (100 ng/kg) (1 pg/kg-100 pg/kg) produced significant reduction latency. maximal was 15 min after these drugs. Neither pg/kg-1 μg/kg) nor induced any (50 increased only 5 injection. These findings indicate that induces thermal hyperalgesia through analgesia by action rats.
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