Epstein-Barr Virus Infection and Lymphoproliferative Disorder After Hematopoietic Cell Transplantation
作者： Yazhen Zhong
关键词: Disease 、 Rituximab 、 Virus 、 Immune system 、 Monoclonal antibody 、 Cytotoxic T cell 、 Epstein–Barr virus infection 、 Medicine 、 Transplantation 、 Immunology 、 Oncology(nursing) 、 Oncology
摘要: Common herpes viruses such as Epstein-Barr virus (EBV) cause infection and disease after hematopoietic cell transplantation (HCT). Post-transplantation lymphoproliferative disorder following allogeneic HCT is a rare but life-threatening disease, mostly associated with EBV-infected B cells. Anti-CD20 monoclonal antibodies (e.g., rituximab) target normal infected cells further suppress the patient's immune system. This article describes development of cellular therapies by infusing virus-specific cytotoxic T lymphocytes via IV into patients to create an adoptive system for specific viral suppression.
metapress.com参考文章(17)
Donna A. Shriner, Gérard Socié, Douglas W. Kingma, H. Joachim Deeg, Mary M. Horowitz, Robert Peter Gale, Joseph F. Fraumeni, Elaine S. Jaffe, Robert P. Witherspoon, George E. Sale, Daniel J Weisdorf, Rochelle E. Curtis, Philip A. Rowlings, Hans Jochem Kolb, Peter M. Banks, Kathleen A. Sobocinski, Keith M. Sullivan, Lois B. Travis, Robert N. Hoover, Risk of lymphoproliferative disorders after bone marrow transplantation: a multi-institutional study. Blood. ,vol. 94, pp. 2208- 2216 ,(1999) , 10.1182/BLOOD.V94.7.2208.419K21_2208_2216
Thomas G. Gross, Posttransplant Lymphoproliferative Disease (PTLD) in Hematopoietic Stem Cell Transplantation (HSCT) Springer, Berlin, Heidelberg. pp. 173- 182 ,(2010) , 10.1007/978-3-642-01653-0_14
Upton D. Allen, Clinical Features and Diagnostic Evaluation of Posttransplant Lymphoproliferative Disorder Post-Transplant Lymphoproliferative Disorders. pp. 69- 88 ,(2010) , 10.1007/978-3-642-01653-0_6
Ingrid Kuehnle, M. Helen Huls, Zhensheng Liu, Micah Semmelmann, Robert A. Krance, Malcolm K. Brenner, Cliona M. Rooney, Helen E. Heslop, CD20 monoclonal antibody (rituximab) for therapy of Epstein-Barr virus lymphoma after hemopoietic stem-cell transplantation. Blood. ,vol. 95, pp. 1502- 1505 ,(2000) , 10.1182/BLOOD.V95.4.1502.004K40_1502_1505
Y Fujita, C M Rooney, H E Heslop, Adoptive cellular immunotherapy for viral diseases Bone Marrow Transplantation. ,vol. 41, pp. 193- 198 ,(2008) , 10.1038/SJ.BMT.1705906
Juliet N. Barker, Ekaterina Doubrovina, Craig Sauter, Jennifer J. Jaroscak, Miguel A. Perales, Mikhail Doubrovin, Susan E. Prockop, Guenther Koehne, Richard J. O'Reilly, Successful treatment of EBV-associated posttransplantation lymphoma after cord blood transplantation using third-party EBV-specific cytotoxic T lymphocytes Blood. ,vol. 116, pp. 5045- 5049 ,(2010) , 10.1182/BLOOD-2010-04-281873
Hans-Joachim Wagner, Cliona M Rooney, Helen E Heslop, Diagnosis and treatment of posttransplantation lymphoproliferative disease after hematopoietic stem cell transplantation. Biology of Blood and Marrow Transplantation. ,vol. 8, pp. 1- 8 ,(2002) , 10.1053/BBMT.2002.V8.PM11846351
John E Wagner, Juliet N Barker, Paul L Martin, James E Coad, Todd DeFor, Michael E Trigg, Joanne Kurtzberg, Daniel J Weisdorf, Low incidence of Epstein-Barr virus-associated posttransplantation lymphoproliferative disorders in 272 unrelated-donor umbilical cord blood transplant recipients. Biology of Blood and Marrow Transplantation. ,vol. 7, pp. 395- 399 ,(2001) , 10.1053/BBMT.2001.V7.PM11529490
Catherine M Bollard, Ingrid Kuehnle, Ann Leen, Cliona M Rooney, Helen E Heslop, Adoptive immunotherapy for posttransplantation viral infections Biology of Blood and Marrow Transplantation. ,vol. 10, pp. 143- 155 ,(2004) , 10.1016/J.BBMT.2003.09.017
J. Styczynski, H. Einsele, L. Gil, P. Ljungman, Outcome of treatment of Epstein–Barr virus‐related post‐transplant lymphoproliferative disorder in hematopoietic stem cell recipients: a comprehensive review of reported cases Transplant Infectious Disease. ,vol. 11, pp. 383- 392 ,(2009) , 10.1111/J.1399-3062.2009.00411.X