Uniform-sized molecularly imprinted polymer for (S)-ibuprofen retention properties in aqueous mobile phases.
作者： Jun Haginaka , Haruyo Sanbe , Hisako Takehira
DOI: 10.1016/S0021-9673(99)00764-5
关键词: Selectivity 、 Enantiomer 、 Swelling 、 Polymerization 、 Chemistry 、 Chromatography 、 Aqueous solution 、 Molecular imprinting 、 Molecularly imprinted polymer 、 Ethylene glycol dimethacrylate
摘要: A uniform-sized molecularly imprinted polymer for (S)-ibuprofen has been prepared by a multi-step swelling and thermal polymerization method using 4-vinylpyridine (4-VPY) ethylene glycol dimethacrylate (EDMA) as host functional monomer cross-linker, respectively. The obtained 4-VPY-EDMA materials were evaluated aqueous eluents HPLC. Hydrophobic hydrogen bonding interactions between ibuprofen enantiomers could play an important role in the retentivity enantioselectivity. Further, partial resolution of metabolites, 2-hydroxy- 2-carboxyibuprofen, was attained with materials.
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