Aminophylline, Adenosine Antagonist Attenuates Glycerol-Induced Acute Renal Failure in Rats
作者： Hamoudi Mousah , Ali Aldallal , Sabah Al-Thamir
DOI:
关键词: Pharmacology 、 Anesthesia 、 Renal function 、 Renal damage 、 Blood urea nitrogen 、 Creatinine 、 Adenosine receptor 、 Aminophylline 、 Medicine 、 Glycerol
摘要: we investigate the effect of Aminophylline against acute renal failure (ARF) in female Albino Wister rats. ARF was produced by glycerol as a simple method for induction so this achieved injection single dose (10ml/kg, 50%V/V with tap water, IM) rats which were restricted to drinking water 24 hours. (5mg/rat I.P) administered at (60min.'s) before ARF. The blood urea nitrogen ( BUN ) and serum creatinine Scr concentrations markedly elevated glycerol-ARF group on 1 st day 3 rd day, but elevation significantly suppressed Aminophylline. Also attenuated severe impairment clearance Crcl caused glycerol. Conclusion: These findings suggest that can protect damage Key words : ARF, glycerol,
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