Long Term Effects of Administration of a Gonadotropin Releasing Hormone Superagonist Analog in Men with Prostatic Carcinoma

摘要: Administration of the superagonist analog GnRH, D-Leu6-GnRH proethylamide, profoundly reduced plasma LH, FSH, testosterone, and dihydrotestosterone levels when given for 6–11 weeks to adult men with prostatic carcinoma. Since patients carcinoma can be expected receive this as long 3–4 yr, we questioned whether same degree reduction could maintained during chronic administration. In 22 who had received proethylamide at least 1 LH testosterone remained initial low levels. Plasma concentrations, on other hand, gradually fell further term FSH reached a nadir 5.7 ± 0.94 (± SEM) mlU/ml 10–11 weeks. Unexpectedly, gonadotropin then increased, between 25 97 were approximately 10–15 mlU/ml. This pattern occurred identically in receiving either or 10 mg daily. These data indicate persistent...