Effect of diphenylhydantoin on pituitary-adrenal interrelations.

摘要: ABSTRACT This report describes the effect of short-term administration therapeutic amounts diphenylhydantoin (Dilantin) on adrenal cortical function in 8 normal adults. The integrity pituitary-adrenal axis was evaluated by measuring alterations urinary excretion 17-hydroxycorticosteroids after oral SU-4885 (Metopirone). Adrenal responsiveness assessed determining increase plasma 17-hydroxycorticosteroid levels following intramuscular ACTH gel. These studies were performed before and during administration. Before receiving diphenylhydantoin, all subjects had a response to ACTH, an increased SU-4885. While unaltered subjects, whereas 7 now manifested abnormal In 3, this characterized la...