Dendritic cells in the eye
作者： Paul G McMenamin , John V Forrester , TL Michael , WT Angus
DOI: 10.1016/B978-012455851-9/50068-7
关键词: Cell biology 、 Cytokine 、 Precursor cell 、 Antigen-presenting cell 、 Iris (anatomy) 、 Tumor necrosis factor alpha 、 Antigen 、 Retinal pigment epithelium 、 Primordium 、 Immunology 、 Biology
摘要: The development of Ia + dendritic cells (DCs) in the aqueous outflow pathways and iris rat eye may occur more slowly than that observed other tissue sites. It appears DCs infiltrate primordium as Ox62 /Ia - or lo precursor cells, which subsequently develop situ into bearing high levels antigen. purified by positive immunomagnetic selection have functional capacity to stimulate naive T a mixed lymphocyte response (MLR) similar conventional DCs, such Langerhans (LCs). Iris like “immature” peripheral tissues, are weak antigen presenting (APCs), require appropriate cytokine maturational signals, GM-CSF order display potent stimulatory an MLR assay. In eye, retinal pigment epithelium (RPE) also known release GM-CSF, is survival factor for DCs. Production RPE induced cytokines TGFβ, TNFα, IL-1.
elsevier.com
sci-hub.st 参考文章(107)
R D Granstein, T J Flotte, M E Sherwood, T L Knisely, D M Albert, T M Anderson, Morphologic and ultrastructural examination of I-A+ cells in the murine iris. Investigative Ophthalmology & Visual Science. ,vol. 32, pp. 2423- 2431 ,(1991)
M E De Stefano, E Mugnaini, Fine structure of the choroidal coat of the avian eye. Lymphatic vessels. Investigative Ophthalmology & Visual Science. ,vol. 38, pp. 1241- 1260 ,(1997)
Raymond J. Steptoe, Patrick G. Holt, Paul G. McMenamin, Major histocompatibility complex (MHC) class II--positive dendritic cells in the rat iris. In situ development from MHC class II-negative precursors. Investigative Ophthalmology & Visual Science. ,vol. 38, pp. 2639- 2648 ,(1997)
J M Liversidge, J V Forrester, H F Sewell, Human retinal pigment epithelial cells differentially express MHC class II (HLA, DP, DR and DQ) antigens in response to in vitro stimulation with lymphokine or purified IFN-gamma. Clinical and Experimental Immunology. ,vol. 73, pp. 489- 494 ,(1988)
Janet Liversidge, John V. Forrester, Parwez Hossain, Peter F. Sharp, Pedro Vieira, Gary C. Brown, Michael J. Cree, A. Manivannan, In vivo cell tracking by scanning laser ophthalmoscopy: quantification of leukocyte kinetics. Investigative Ophthalmology & Visual Science. ,vol. 39, pp. 1879- 1887 ,(1998)
John V. Forrester, Paul G. McMenamin, Janet Liversidge, Lynne Lumsden, Dendritic Cells and “Dendritic” Macrophages in the Uveal Tract Advances in Experimental Medicine and Biology. ,vol. 329, pp. 599- 604 ,(1993) , 10.1007/978-1-4615-2930-9_100
Geeta Pararajasegaram, Narsing A. Rao, Guey-Shuang Wu, Takashi Matsubara, Takashi Matsubara, Retinal Microglia Differentially Express Phenotypic Markers of Antigen-Presenting Cells In Vitro Investigative Ophthalmology & Visual Science. ,vol. 40, pp. 3186- 3193 ,(1999)
Paul Mcmenamin, R.J. Steptoe, P.G. Holt, Functional studies of major histocompatibility class II-positive dendritic cells and resident tissue macrophages isolated from the rat iris. Immunology. ,vol. 85, pp. 630- 637 ,(1995)
Kayo Inaba, Muneo Inaba, Margit Witmer-Pack, Karen Hathcock, Richard Hodes, Ralph M. Steinman, Expression of B7 Costimulator Molecules on Mouse Dendritic Cells Advances in Experimental Medicine and Biology. ,vol. 378, pp. 65- 70 ,(1995) , 10.1007/978-1-4615-1971-3_13
T.L. Butler, Paul Mcmenamin, Resident and Infiltrating Immune Cells in the Uveal Tract in the Early and Late Stages of Experimental Autoimmune Uveoretinitis Investigative Ophthalmology & Visual Science. ,vol. 37, pp. 2195- 2210 ,(1996)