Experimental inhibition of peptide fibrillogenesis by synthetic peptides, carbohydrates and drugs.

摘要: Peptide fibrillogenesis generally begins by the transformation of normally soluble proteins into elongated aggregates which are called as amyloid. These fibrils mainly consist s-sheets. They share certain common characteristics such a cross-s x-ray diffraction pattern, association with other and typical staining dye Congo Red. The individual form deposit consists disease-specific peptide/protein. protein serves basis for classification amyloids. fibril-forming peptides/proteins diseases makes them primary disease-targets. Understanding molecular interactions involved in fibril formation becomes foremost requirement to characterize target. Interference these s-sheets vitro prevents sometimes reverses assembly. A small molecule capable interfering could have therapeutic applications diseases. This anti-aggregation approach appears be viable treatment option. search is pursued actively world over. All types compounds approaches slow down or prevent aggregation process been described literature. efforts reviewed this chapter.