Zirconium oxy dichloride octahydrate: a green Lewis acid catalyst for the synthesis of novel 3-[(alkyl/arylthio)(aryl)methyl]-1H-indoles
作者： Kobra Nikoofar , Samareh Gorji
DOI: 10.1007/S11164-016-2521-Z
关键词: Aryl 、 Cascade reaction 、 Catalysis 、 Multi-component reaction 、 Zirconium 、 Organic chemistry 、 Lewis acid catalysis 、 Chemistry 、 Alkyl 、 Reaction conditions
摘要: Some novel 3-[(alkyl/arylthio)(aryl)methyl]-1H-indoles (4a–h) are prepared via a one-pot, three-component, and domino reaction of indoles, aromatic aldehydes, various (hetero) thiols in the presence zirconium oxy dichloride octahydrate as an efficient green Lewis acid catalyst. Mild conditions, simple procedure, good yields products, inexpensive eco-friendly catalyst usage, lack by-products formation, such dithioacetals from well bis(indolyl)methanes, highlighted points presented protocol.
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