Kappa opioid receptors modulate cardiorespiratory function in hindbrain nuclei of rat.
作者： AH Hassen , G Feuerstein , AI Faden
DOI: 10.1523/JNEUROSCI.04-09-02213.1984
关键词: Respiratory rate 、 κ-opioid receptor 、 Endocrinology 、 Anesthesia 、 (+)-Naloxone 、 Opioid 、 Bremazocine 、 Microinjection 、 Solitary nucleus 、 Dynorphin 、 Internal medicine 、 Chemistry
摘要: The respiratory and cardiovascular effects of selective kappa opioid agonists were compared following microinjection (0.1 microliter) into the nucleus ambiguus (NA) tractus solitarius (NTS) regions spontaneously breathing artificially respired pentobarbital-anesthetized rats. In animals, benzomorphan derivative MRZ 2549 (MRZ, 3 X 10(-11) to 16 10(-9) mol) elicited dose-related decreases mean arterial pressure (MAP), heart rate (HR), tidal volume (TV) NA injection; bremazocine (BREM) decreased MAP, HR, (RR). Following NTS injection, (3 10(-10) lowered MAP TV, highest dose also lowering HR RR; BREM HR. Naloxone (200 micrograms/kg, i.v.) reversed without consistently altering activity. ventilated injections or a decrease These responses not by naloxone. stereoisomer (+ BREM) was effect at similar doses mol). (16 naloxone-reversible tachycardia injection in animals; no other observed administration lower MRZ. Dynorphin (1-13) (6 60 significantly microinjections injections.(ABSTRACT TRUNCATED AT 250 WORDS)
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