Blood-brain barrier dysfunction in disorders of the developing brain

摘要: Disorders of the developing brain represent a major health problem. The neurological manifestations lesions can range from severe clinical deficits to more subtle signs or behavioral problems and learning disabilities, which often become evident many years after initial damage. These long-term sequelae are due at least in part central nervous system immaturity time insult. blood-brain barrier (BBB) protects maintains homeostasis. BBB alterations observed during both acute chronic insults. After an insult, excitatory amino acid neurotransmitters released, causing reactive oxygen species (ROS)-dependent changes permeability that allow immune cells enter stimulate inflammatory response. cytokines, chemokines other molecules released as well peripheral local activate cascade brain, leading secondary neurodegeneration continue for months even finally contribute post-insult neuronal deficits. role perinatal disorders is poorly understood. response, be either (e.g., stroke, traumatic injury) infectious diseases) actively modulates pathophysiological processes underlying injury. We present overview current knowledge about dysfunction insults, along with experimental data.