Increased Expression of the Vascular Endothelial Growth Factor Is a Pejorative Prognosis Marker in Papillary Thyroid Carcinoma

摘要: Vascular endothelial growth factor (VEGF) is a potent stimulator of cell proliferation. It has been implicated in tumor human thyroid carcinomas. Using the VEGF immunohistochemistry staining score, we correlated level expression with metastatic spread 19 cases papillary carcinoma. The immunostaining ranging from 0-9, was determined as multiplication percentage labeled thyrocytes score (0, no labeling; 1, 61% thyrocytes) and an intensity staining; weak; 2, mild; 3, strong staining). mean +/- SD 5.74 2.59 for all carcinoma 8.25 1.13 vs. 3.91 1.5 nonmetastatic cancers (P < 0.001). By discriminant analysis, found threshold value 6.0, sensitivity 100% specificity 87.5%. There were statistical differences between carcinomas when age, size, or thyroglobulin levels considered. seems to be helpful marker metastasis differentiated cancers. An increased production could assess aggressive disease hallmark trend produce metastasis. We propose prognosis A 6 more, should considered at high risk threat, prompting physician institute tight follow up patient.