Choice of Antiepileptic Drug, Which One to Try First and What to Do if it Fails ...

摘要: INTRODUCTION The prevalence of treated epilepsy in the UK is about 80 per 100 000 people (Wallace et al. 1998). Antiepileptic drugs (AEDs) produce remission seizures 60–70% with (Kwan & Brodie 2000) but many withdraw from AEDs because lack efficacy, an adverse effect, or both (Mattson 1985; Marson 1997). Holy Grail epilepsy, AED that 100% effective has no effects drug interactions, remains elusive. So how should we choose which to give first and, if fails, be tried next? Choice crucial as patients remain on for years (Lhatoo 2001). This article not intended some foolproof ‘neurological recipe’, rather a guide based current evidence, however imperfect, and experience success failure over