The Anti-Inflammatory Effects of Heat Shock Protein 72 Involve Inhibition of High-Mobility-Group Box 1 Release and Proinflammatory Function in Macrophages

作者: Daolin Tang , Rui Kang , Weimin Xiao , Haichao Wang , Stuart K. Calderwood

DOI: 10.4049/JIMMUNOL.179.2.1236

关键词: Nuclear proteinNFKB1MAPK/ERK pathwayHMGB1Proinflammatory cytokineHeat shock proteinTransport proteinBiologyCell biologyMolecular biologyp38 mitogen-activated protein kinases

摘要: … stress-inducible protein, heat shock protein 72 (Hsp72) by gene transfection attenuated LPS- or TNF-α-… This suggests that MAPKs and NF-κB pathways are important signal pathways …

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