Antioxidant enzymes in erythrocytes from hypertension patients receiving lisinopril monotherapy or combined lisinopril plus simvastatin therapy

摘要: Statins and angiotensin-converting enzyme (ACE) inhibitors have beneficial impact on the serum cholesterol blood pressure. It is supposed that statins ACE may modify antioxidative status of erythrocytes. The study objective was to compare effects two treatments, lisinopril alone vs plus simvastatin, erythrocyte antioxidant activities. involved 32 patients with arterial hypertension, initial total cholesterol, LDL-cholesterol triglycerides within normal range. Patients groups, each 16 subjects, were treated (10 mg/day) or simvastatin (20 mg/day). Before after 3 6 months follow-up therapy, activities superoxide dismutase (SOD), catalase, glutathione peroxidase (GPx), reductase (GLR) in purified erythrocytes determined. In all patients, significantly higher catalase activity (by 79.3-106.5%, p < 0.0001) lower GPx 20.7-30.6%, 0.001) observed therapy as compared baselines. Just same results obtained both groups (lisinopril + simvastatin), periods (3 month) treatments. SOD increased only group (p = 0.0345). No changes GLR seen under conditions indicated. Thus, monotherapy combined exhibit specific, pronounced equipotent enzymes human Administration protect other tissues from oxidative damage.