Hijacking of Host Cell Signaling byTheileria

摘要: The apicomplexan parasites Theileria annulata and T. parva possess the ability to transform infected host cell induce uncontrolled proliferation. Residing free in cytosol of its leukocyte, schizont is a perfect position manipulate signaling pathways involved regulating apoptosis, proliferation, motility. While extensive Theileria-induced changes protein phosphorylation patterns have been reported, no Theileria-encoded kinases or phosphatases demonstrated - are even predicted be associated with surface secreted into cell. Instead, it seems that has evolved capacity modulate In certain cases this involves “hijacking” pivotal kinases, such as IκB kinase complex mitotic polo-like 1, recruiting them surface. chapter current understanding activation reviewed, an attempt made link these events phenotypic occur response infection.