Afghan Hindu Kush: Where Eurasian Sub-Continent Gene Flows Converge

摘要: Despite being located at the crossroads of Asia, genetics Afghanistan populations have been largely overlooked. It is currently inhabited by five major ethnic populations: Pashtun, Tajik, Hazara, Uzbek and Turkmen. Here we present autosomal from a subset our samples, mitochondrial Y- chromosome data over 500 Afghan samples among these 5 groups. This was supplemented with same Y-chromosome analyses Iran, Kyrgyzstan, Mongolia updated Pakistani (HGDP-CEPH). The presented here integrated into existing knowledge pan-Eurasian genetic diversity. pattern variation, revealed structure-like Principal Component Analysis Molecular Variance indicates that people are made up mosaic components representing various geographic regions Eurasian ancestry. absence Central Asian-specific component Hindu Kush, like gene pool Asian in general, confluence flows rather than source distinctly autochthonous arisen situ: conclusion reinforced phylogeography both haploid loci.