Des-asp1-angiotensin I: A metabolite of angiotensin I in the perfused feline adrenal
作者： John A. Ackerly , Theodore S. Felger , Michael J. Peach
DOI: 10.1016/0014-2999(76)90207-7
关键词: Secretagogue 、 Angiotensin II 、 Renin–angiotensin system 、 Angiotensin-converting enzyme 、 Adrenal medulla 、 Adrenal gland 、 Endocrinology 、 Chemistry 、 Internal medicine 、 Adrenal cortex 、 Metabolite 、 Pharmacology
摘要: Abstract The administration of radioactive angiotensin I to the retrogradely perfused feline adrenal gland caused a brisk discharge catecholamines. Recovery labelled decapeptide and metabolites in effluent fluid was complete 5 min. Radioimmunoassay this perfusate revealed that most peptide remained as I, but chromatographic electrophoretic evaluation indicated > 68% had been metabolized des-asp 1 -angiotensin I. absence II, II or his- 3 H-leu suggested minimal dipeptidyl carboxypeptidase activity preparation. In addition, profile from not altered by treatment with converting enzyme inhibitor B. jararaca nonapeptide. very weak secretagogue medulla. If metabolism nonapeptide occurs medulla, may represent pathway limit secretory action These results suggest high degree aminopeptidase which be primarily localized cortex.
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