Iron-heme-Bach1 axis is involved in erythroblast adaptation to iron deficiency

摘要: Iron plays the central role in oxygen transport by erythrocytes as a constituent of heme and hemoglobin. The importance iron is also to be found their regulatory roles during erythroblast maturation. transcription factor Bach1 may involved since it deactivated direct binding heme. To address whether responses erythroblasts status, low conditions that induced severe deficiency mice were established. Under deficiency, extensive gene expression changes mitophagy disorder maturation erythroblasts. Bach1−/− showed more anemia developmental phase retarded recovery once was replenished when compared with wild-type mice. In absence Bach1, globin genes Hmox1 (encoding oxygenase-1) de-repressed under suggesting represses these balance levels globin. Moreover, an increase genome-wide DNA methylation observed deficiency. These findings reveal principle regulator suggest iron-heme-Bach1 axis important for proper adaptation avoid toxic aggregates non-heme