Potential future application with therapeutic agents

作者: Harold L. Atkins

DOI: 10.1016/S0001-2998(79)80044-6

关键词: Cancer researchIntracellularOsteosarcomaLiposomeMedicineCell cultureIrradiationImmunologyRadiation therapyIonizing radiationCell killing

摘要: Several new approaches to radiation therapy with radionuclides have been discussed. Iron 55 is selectively utilized in the red cell developmental cycle and therapeutic doses, can lower marrow circulating erythrocyte levels much smaller degrees of effect on other lines. A serious complication, noted animal studies, induction neoplasma, especially osteosarcoma. Selective irradiation nucleus possible 125 IUdR. This results highly efficient killing due concentrated region ionization. High concentrations densely ionizing malignant may also be accomplished 211 At. The use labeled liposomes an additional approach delivery intracellular irradiation. None these applicable for practical treatment human malignancy at present time. importance their value as models future development methods that provide selective target sites.

参考文章(49)
J. A. Smit, J. A. Myburgh, R. D. Neirinckx, Specific inactivation of sensitized lymphocytes in vitro using antigens labelled with astatine-211. Clinical and Experimental Immunology. ,vol. 14, pp. 107- ,(1973)
Richard Paul Spencer, Therapy in nuclear medicine Grune & Stratton. ,(1978)
George Poste, Demetrios Papahadjopoulos, William J. Vail, Lipid vesicles as carriers for introducing biologically active materials into cells. Methods in Cell Biology. ,vol. 14, pp. 33- 71 ,(1976) , 10.1016/S0091-679X(08)60468-9
E. DIANE NEERUNJUN, GREGORY GREGORIADIS, Tumour Regression with Liposome-Entrapped Asparaginase: Some Immunological Advantages Biochemical Society Transactions. ,vol. 4, pp. 133- 134 ,(1976) , 10.1042/BST0040133
Jean A. Laissue, Eugene P. Cronkite, Harold Burlington, Ursula Reincke, Induction of Osteosarcomas and Hematopoietic Neoplasms by 55Fe in Mice Cancer Research. ,vol. 37, pp. 3545- 3550 ,(1977)
U. Reincke, H. Burlington, E. P. Cronkite, J. Laissue, Hayflick's hypothesis: an approach to in vivo testing. Fed. Proc.; (United States). ,vol. 34, pp. 71- 75 ,(1975) , 10.1007/978-1-4684-2631-1_15
L. E. Feinendegen, Biological damage from the Auger effect, possible benefits. Radiation and Environmental Biophysics. ,vol. 12, pp. 85- 99 ,(1975) , 10.1007/BF01328970
Peter Weidinger, PhilipM. Johnson, SidneyC. Werner, Five years' experience with iodine-125 therapy of Graves' disease. The Lancet. ,vol. 304, pp. 74- 77 ,(1974) , 10.1016/S0140-6736(74)91636-5
Z. Lewitus, E. Lubin, J. Rechnic, M. Ben-Porath, Y. Feige, Treatment of thyrotoxicosis with 125I and 131I Seminars in Nuclear Medicine. ,vol. 1, pp. 411- 421 ,(1971) , 10.1016/S0001-2998(71)81036-X
Brenda E. Ryman, R. F. Jewkes, K. Jeyasingh, M. P. Osborne, H. M. Patel, V. J. Richardson, M. H. N. Tattersall, D. A. Tyrrell, POTENTIAL APPLICATIONS OF LIPOSOMES TO THERAPY Annals of the New York Academy of Sciences. ,vol. 308, pp. 281- 307 ,(1978) , 10.1111/J.1749-6632.1978.TB22031.X