Generation of recognition diversity in the nervous system
作者： Dietmar Schmucker , John G. Flanagan
DOI: 10.1016/J.NEURON.2004.10.004
关键词: Surface protein 、 Biology 、 Gene isoform 、 Receptor 、 Diversity (business) 、 Axon Fasciculation 、 Neuroscience 、 Communication 、 Nervous system 、 DSCAM 、 Neuron
摘要: For decades, it has been suggested that complex neural wiring might be specified by extensive diversity in receptor isoforms. Dscam is a cell surface protein with 38,016 potential alternatively spliced isoforms the fly nervous system. Remarkable binding studies now show isoform indeed results an unprecedented level of recognition diversity, showing isoform-specific homophilic binding. In vivo have begun to suggest models for use neuron-target recognition, axon fasciculation, and neuron self-recognition.
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