Raman Spectroscopic Imaging for the Real‐Time Detection of Chemical Changes Associated with Docetaxel Exposure

摘要: There is an urgent need for methods allowing a fast, non-invasive, sensitive and selective monitoring of the effectiveness anticancer drugs during course chemotherapeutic treatment cancer patients. The possibility predicting controlling efficiency agents every patient individually enables personalized therapy with largely improved success rates. results presented herein demonstrate that Raman microspectroscopy perfectly suited to monitor impact on living cells. influence clinically well-established docetaxel both morphology also biochemistry colon cells (HT-29) has been studied by means spectroscopy in combination modern chemometric approaches. work paves way establishing as tool chemotherapy can therefore be seen step towards therapy.