Formation and Metabolism of 7alpha-Hydroxy-5alpha-cholestan-3-one and 7alpha,12alpha-Dihydroxy-5alpha-cholestan-3-one in Rat Liver
作者： I. Bjorkhem , K. Einarsson
DOI: 10.1111/J.1432-1033.1970.TB00915.X
关键词: Cholestanes 、 Chemistry 、 Rat liver microsomes 、 Biochemistry 、 Allocholic acid 、 Metabolism 、 Tritium 、 Endocrinology 、 Microsome 、 Cofactor 、 Internal medicine 、 Rat liver 、 Cell biology 、 Molecular biology
摘要: The synthesis of 7α-hydroxy-5α-cholestan-3-one and 7α,12α-dihydroxy-5α-cholestan-3-one is described. These compounds were shown to be formed from the corresponding Δ4-3-oxo-steriods in presence rat liver microsomes fortified with NADPH or an NADPH-generating system. Liver female rats three four times more active than those male rats. In NADH NADPH, was converted into 5α-cholestane-3β,7α-diol. preferred cofactor. 7α-Hydroxy-5α-cholestan-3-one mainly allocholic acid bile fistula role microsomal Δ4-3-oxosteroid 5α-reductase formation 5α-bile acids discussed.
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