The significance of a nineteenth century definition in the era of genomics: linitis plastica.

摘要: Linitis plastica due to gastric adenocarcinoma is a condition with long history, but still lacks standardized definition and commonly confused Borrmann type IV, Lauren diffuse, signet-cell cancer. The absence of clear problem when investigating its biological characteristics role as possible independent factor for prognosis. Nevertheless, the behavior linitis plastica, which unique, may be valuable in risk stratification have implications treatment. A based on molecular or genomic criteria could represent useful starting point new targeted therapies. This literature review will focus current classifications cancer, illustrating how concept relates them most cases identifying reproducible definition. Moreover, highlight diagnostic challenges associated prognostic implications, therapeutic options available. Future perspectives management are also addressed. carcinoma scirrhous stroma, involving submucosal muscular layers stomach even mucosal alteration. In cases, primary cancer cells signet-ring scattered context poorly differentiated carcinoma. Diagnosis challenging. Staging should thorough, including laparoscopy all high incidence peritoneal involvement. significance controversial. Curative-intent surgery, feasible, performed, multimodality treatment approach. Cancer-stroma interactions important features this disease, attaining potential target future pathologic assessments report stromal reaction order allow better characterization tumor.