Irreversible electroporation: a drug-free cancer treatment

摘要: Abstract: Many potential drugs to treat cancer have found limited success, due the lack of safe and efficient delivery systems that allow molecules cross hydrophilic hydrophobic lipid bilayers cell plasma membranes, which are normally impermeable. It would be ideal a treatment is drug-free, alleviating side effects, cost drug resistance. Electroporation could used for targeted drug-less treatment, known as irreversible electroporation (IRE), where higher voltages longer more pulses, compared conventional electroporation, kill tumor cells. This causes permanent permeabilization membranes consequent loss homeostasis. study evaluates effects various parameters on different lines were treated with pulse parameters. The viability results indicate differences in viabilities hence aggressiveness experimented IRE needed obtain desired effect proliferation control complete ablation.