Role of natriuretic peptide signaling in modulating asthma and inflammationThis article is one of a selection of papers published in the Special Issue on Recent Advances in Asthma Research.
作者： Shyam S. Mohapatra
DOI: 10.1139/Y07-066
关键词: Signal transduction 、 Atrial natriuretic peptide 、 Natriuretic peptide 、 Hormone 、 Peptide 、 Asthma 、 Medicine 、 Inflammation 、 Respiratory disease 、 Immunology 、 Physiology (medical) 、 Physiology 、 Pharmacology 、 General Medicine
摘要: Atrial natriuretic peptide (ANP), the C-terminal peptide comprising residues 99–126 of the pro-ANP hormone, has been studied for 3 decades for its cardiovascular effects. Recent reports suggest that it plays a significant role in modulation of the immune system. Immune cells, including macrophages, dendritic cells, and T lymphocytes, express receptors for ANP. ANP plays a significant role in shaping the early immune response to environmental antigens and may play a critical role in the interaction between cells of the innate and adaptive immune systems; it also appears to be involved in polarizing the immune response to allergens. Thus, ability to alter the magnitude of natriuretic peptide receptor A (NPRA) signaling could be exploited to develop therapeutics for several allergic diseases, including asthma. This report will review and critically evaluate the role of the ANP pathway in asthma and inflammation.
nrcresearchpress.com参考文章(69)
J Bełtowski, [N-terminal atrial natriuretic peptides]. Postȩpy higieny i medycyny doświadczalnej. ,vol. 54, pp. 895- 914 ,(2000)
T.D. Chrisman, S. Schulz, L.R. Potter, D.L. Garbers, Seminal plasma factors that cause large elevations in cellular cyclic GMP are C-type natriuretic peptides Journal of Biological Chemistry. ,vol. 268, pp. 3698- 3703 ,(1993) , 10.1016/S0021-9258(18)53749-2
Kunio S. Misono, Natriuretic peptide receptor: structure and signaling. Molecular and Cellular Biochemistry. ,vol. 230, pp. 49- 60 ,(2002) , 10.1007/978-1-4615-0927-1_3
Takashi Agui, Xiaonan Xin, Yiqiang Cai, Giljin Shim, Youji Muramatsu, Takahisa Yamada, Hiromi Fujiwara, Kozo Matsumotoup, Opposite Actions of Transforming Growth Factor-β1 on the Gene Expression of Atrial Natriuretic Peptide Biological and Clearance Receptors in a Murine Thymic Stromal Cell Line Journal of Biochemistry. ,vol. 118, pp. 500- 507 ,(1995) , 10.1093/OXFORDJOURNALS.JBCHEM.A124936
Yasato Komatsu, Kazuwa Nakao, Hiroshi Itoh, Shin-Ichi Suga, Yoshihiro Ogawa, Hiroo Imura, Vascular natriuretic peptide. The Lancet. ,vol. 340, pp. 622- ,(1992) , 10.1016/0140-6736(92)92167-E
Ali Pedram, Mahnaz Razandi, Ellis R. Levin, Deciphering vascular endothelial cell growth factor/vascular permeability factor signaling to vascular permeability. Inhibition by atrial natriuretic peptide. Journal of Biological Chemistry. ,vol. 277, pp. 44385- 44398 ,(2002) , 10.1074/JBC.M202391200
David L. Vesely, Gloria I. Perez-Lamboy, Douglas D. Schocken, Long-acting natriuretic peptide, vessel dilator, and kaliuretic peptide enhance the urinary excretion rate of β2-Microglobulin Metabolism-clinical and Experimental. ,vol. 49, pp. 1592- 1597 ,(2000) , 10.1053/META.2000.18557
Robert M. Angus, M. Jane A. McCallum, Geoffrey Hulks, Neil C. Thomson, Bronchodilator, cardiovascular, and cyclic guanylyl monophosphate response to high-dose infused atrial natriuretic peptide in asthma. The American review of respiratory disease. ,vol. 147, pp. 1122- 1125 ,(1993) , 10.1164/AJRCCM/147.5.1122
D Vesely, Atrial natriuretic peptides in pathophysiological diseases. Cardiovascular Research. ,vol. 51, pp. 647- 658 ,(2001) , 10.1016/S0008-6363(01)00256-5
Ronald B. Moss, Marc G. Golightly, In vitro enhancement of natural cytotoxicity by a trial natriuretic peptide fragment 4–28 Peptides. ,vol. 12, pp. 851- 854 ,(1991) , 10.1016/0196-9781(91)90145-F