Quercetin supplementation does not enhance cerebellar mitochondrial biogenesis and oxidative status in exercised rats
作者： Rafael A. Casuso , Antonio Martínez-Amat , Fidel Hita-Contreras , Daniel Camiletti-Moirón , Pilar Aranda
DOI: 10.1016/J.NUTRES.2015.05.007
关键词: Mitochondrial biogenesis 、 Sirtuin 1 、 TBARS 、 Endocrinology 、 Antioxidant 、 Biology 、 Citrate synthase 、 Quercetin 、 Oxidative stress 、 Internal medicine 、 Molecular biology 、 Oxidative phosphorylation
摘要: The present study tested the hypothesis that quercetin may inhibit mitochondrial and antioxidant adaptations induced by exercise in cerebellar tissue. Thirty-five 6-week-old Wistar rats were randomly allocated into following groups: quercetin, exercised (Q-Ex; n = 9); sedentary (Q-Sed; no (NQ-Ex; (NQ-Sed; 8). After 6 weeks of supplementation and/or training, cerebellums collected. Protein carbonyl content (PCC), sirtuin 1, peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α), messenger RNA levels, citrate synthase (CS), DNA measured. When Q-Sed was compared with NQ-Sed, PCC (P .01). This effect, however, did not appear Q-Ex < .05). Therefore, we must hypothesize either dose (25 mg/kg) or length period used (or perhaps both) impair exercise-induced
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