Airway Mycosis and the Regulation of Type 2 Immunity.

摘要: Filamentous fungi of the Aspergillus genus and others have long been linked to induction type 2 immunity that underlies IgE-mediated hypersensitivity responses. This unique immune response is characterized by production allergy-associated T helper cell (Th2) Th17 cytokines interleukin 4 (IL-4), IL-13, IL-17 drive IgE, eosinophilia, airway hyperresponsiveness other manifestations asthma. Proteinases secreted filamentous promote immunity, but mechanism which this occurs has remained obscure. Through detailed biochemical analysis household dust, microbiological dissection human secretions, extensive modeling in mice, our laboratory assembled a mechanistic description how evolves after exposure fungi. In review we summarize three key discoveries: (1) fungal proteinases response; (2) relationship between fungi, proteinases, explained mycosis, form non-invasive infection lumen; (3) innate component proteinase-driven mediated cleavage clotting protein fibrinogen. Despite these advances, additional work required understand Th2 responses evolve role non-filamentous potentially play allergic diseases.