Heterogeneity in the Expression of HLA and Tumor-associated Antigens by Surgically Removed and Cultured Breast Carcinoma Cells

摘要: Surgically removed normal and malignant mammary tissues human breast carcinoma cell lines were tested in binding assays with monoclonal antibodies to HLA-A,B,C antigens, β 2-microglobulin, HLA-DR tumor-associated antigens; the latter included a M r 280,000, 94,000, 85,000 membrane-bound glycoprotein cytoplasmic antigen. HLA-A,B antigen are expressed by cells. Their transformation may be associated quantitative changes expression of these antigens appearance 94,000 Mr glycoproteins. The 280,000 was detected on only one tested. Analysis primary tumors autologous axillary lymph node metastasis from 13 patients has shown differences all between metastatic lesions.