Amygdala reactivity in healthy adults is correlated with prefrontal cortical thickness.

摘要: Recent evidence suggests that putting feelings into words activates the prefrontal cortex (PFC) and suppresses response of amygdala, potentially helping to alleviate emotional distress. To further elucidate relationship between brain structure function in these regions, structural functional magnetic resonance imaging (MRI) data were collected from a sample 20 healthy human subjects. Structural MRI processed using cortical pattern-matching algorithms produce spatially normalized maps thickness. During scanning, subjects cognitively assessed an target face by choosing one two linguistic labels (label emotion condition) or matched geometric forms (control condition). Manually prescribed regions interest for left amygdala used extract percentage signal change this region occurring during contrast label versus match forms. A correlation analysis activation thickness was then performed along each point surface, resulting color-coded r value at point. Correlation analyses revealed gray matter ventromedial PFC inversely correlated with task-related amygdala. These add support general role regulating activity