The maternal-fetal relationship in human pregnancy: an immunogenetic perspective.

摘要: Although the mechanisms by which fetal allograft escapes rejection are still poorly understood, abundant evidence has accumulated suggesting multiple roles for major histocompatibility complex (MHC) genes in pregnancy. Specific maternal MHC genotypes and maternal-fetal have been associated with recurrent spontaneous abortion, decreased fecundity, segregation distortions, altered sex ratios, growth rates, autoimmune disease progression. In this review, a variety of gene effects human pregnancy is considered.