5-S-Cysteinyl-dopamine effect on the human dopaminergic neuroblastoma cell line SH-SY5Y.
作者： Luciana Mosca , Eugenio Lendaro , Maria d’Erme , Sonia Marcellini , Sonia Moretti
DOI: 10.1016/J.NEUINT.2006.01.023
关键词: Oxidative stress 、 Superoxide 、 MPTP 、 Dopamine 、 Substantia nigra 、 Dopaminergic 、 Endocrinology 、 Internal medicine 、 SH-SY5Y 、 Reactive oxygen species 、 Chemistry
摘要: In recent years a catechol-thioether metabolite of dopamine, 5-S-cysteinyl-dopamine, has been identified in certain dopaminergic regions the brain, notably Substantia Nigra. 5-S-Cysteinyl-dopamine received great attention view its possible significance as an index oxidative stress aging and neurodegenerative processes, particularly Parkinson's disease. present study effect 5-S-cysteinyl-dopamine on human neuroblastoma SH-SY5Y cells is investigated. The substance highly cytotoxic, even at concentration low 30 microM. Treatment with induce following intracellular responses: decrease mitochondrial transmembrane potential, increase reactive oxygen species such superoxide anion peroxides, marked reduced glutathione inhibition complex I activity. Caspase-3-like protease activation oligonucleosomal DNA fragmentation have also observed. These data are indicative onset apoptotic processes due to 5-S-cysteinyl-dopamine.
core.ac.uk
elsevier.com
sci-hub.se 参考文章(32)
Chien-Tsai Lai, Peter H. Yu, Dopamine- and L-β-3,4-dihydroxyphenylalanine hydrochloride (L-Dopa)-induced cytotoxicity towards catecholaminergic neuroblastoma SH-SY5Y cells : effects of oxidative stress and antioxidative factors Biochemical Pharmacology. ,vol. 53, pp. 363- 372 ,(1997) , 10.1016/S0006-2952(96)00731-9
Jeremy P. E. Spencer, Matthew Whiteman, Peter Jenner, Barry Halliwell, 5-s-Cysteinyl-conjugates of catecholamines induce cell damage, extensive DNA base modification and increases in caspase-3 activity in neurons. Journal of Neurochemistry. ,vol. 81, pp. 122- 129 ,(2002) , 10.1046/J.1471-4159.2002.00808.X
Andrew D. Hope, Rohan De Silva, David F. Fischer, Elly M. Hol, Fred W. Van Leeuwen, Andrew J. Lees, Alzheimer's associated variant ubiquitin causes inhibition of the 26S proteasome and chaperone expression Journal of Neurochemistry. ,vol. 86, pp. 394- 404 ,(2004) , 10.1046/J.1471-4159.2003.01844.X
Maria Rosa Ciriolo, Katia Aquilano, Angelo De Martino, Maria Teresa Carrì, Giuseppe Rotilio, Differential role of superoxide and glutathione in S-nitrosoglutathione-mediated apoptosis: a rationale for mild forms of familial amyotrophic lateral sclerosis associated with less active Cu,Zn superoxide dismutase mutants Journal of Neurochemistry. ,vol. 77, pp. 1433- 1443 ,(2001) , 10.1046/J.1471-4159.2001.00383.X
Nadine A. Tatton, A. Maclean-Fraser, William G. Tatton, Daniel P. Perl, C. Olanow Warren, A fluorescent double-labeling method to detect and confirm apoptotic nuclei in Parkinson's disease. Annals of Neurology. ,vol. 44, ,(1998) , 10.1002/ANA.410440721
Tatyana V. Votyakova, Ian J. Reynolds, ΔΨm‐Dependent and ‐independent production of reactive oxygen species by rat brain mitochondria Journal of Neurochemistry. ,vol. 79, pp. 266- 277 ,(2008) , 10.1046/J.1471-4159.2001.00548.X
Kathrin R. Sidell, Sandra J. Olson, Joyce J. Ou, Yueli Zhang, Ventkataraman Amarnath, Thomas J. Montine, Cysteine and mercapturate conjugates of oxidized dopamine are in human striatum but only the cysteine conjugate impedes dopamine trafficking in vitro and in vivo. Journal of Neurochemistry. ,vol. 79, pp. 510- 521 ,(2008) , 10.1046/J.1471-4159.2001.00586.X
Jing Zhang, Vladimir Kravtsov, Venkataraman Amarnath, Matthew J. Picklo, Doyle G. Graham, Thomas J. Montine, Enhancement of dopaminergic neurotoxicity by the mercapturate of dopamine: relevance to Parkinson's disease. Journal of Neurochemistry. ,vol. 74, pp. 970- 978 ,(2000) , 10.1046/J.1471-4159.2000.0740970.X
Kathleen S. Montine, Kathrin R. Sidell, Jing Zhang, Thomas J. Montine, Dopamine thioethers: formation in brain and neurotoxicity. Neurotoxicity Research. ,vol. 4, pp. 663- 669 ,(2002) , 10.1080/1029842021000045435
Samantha L. Budd, Roger F. Castilho, David G. Nicholls, Mitochondrial membrane potential and hydroethidine‐monitored superoxide generation in cultured cerebellar granule cells FEBS Letters. ,vol. 415, pp. 21- 24 ,(1997) , 10.1016/S0014-5793(97)01088-0