Tissue specific prodrug
作者： Samuel R. Denmeade , John T. Isaacs , S. Brogger Christensen , Hans Lilja
DOI:
关键词: Tissue specific 、 Biochemistry 、 Prostate-specific antigen 、 Cleavage (embryo) 、 Toxicity 、 Cell 、 Medicine 、 Peptide 、 Prodrug
摘要: The invention provides novel peptide prodrugs which contain cleavage sites specifically cleaved by prostate specific antigen (PSA). These are useful for substantially inhibiting the non-specific toxicity of a variety therapeutic drugs. PSA is secreted prostatic glandular cells. Upon prodrug PSA, drugs activated and exert their toxicity. Novel sesquiterpene-γ-lactones also provided invention, designed to be linked carrier moieties such as peptides invention. Methods treating cell proliferative disorders featured in
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