Risk factors associated with methylisothiazolinone contact sensitization.

摘要: SummaryBackground The preservative methylisothiazolinone (MI) has become an important allergen, with a dramatic increase in sensitization prevalence being seen over the last few years. Objective To examine risk factors associated MI sensitization, order to identify targets of prevention aimed at curtailing present epidemic. Methods On basis contact allergy surveillance data collected by Information Network Departments Dermatology (www.ivkd.org), 2009–2012, course 28 922 patch tests MI, 500 ppm water, included series cosmetic preservatives, logistic regression analysis was employed quantify number putative factors. Results The increased from 1.94% 2009 6.02% 2012, mainly driven female patients aged ≥ 40 years, face dermatitis, and use cosmetics. Adjusted multifactorial additionally identified several occupations (e.g. painters beauticians) ano-genital dermatitis as for sensitization. Conclusions The concentrations both industrial, are too high; (self-)regulatory action is urgently needed. should be added baseline series.