Synthesis and vasorelaxant activity of new 1,4-benzoxazine derivatives potassium channel openers.
作者： Giuseppe Caliendo , Elisa Perissutti , Vincenzo Santagada , Ferdinando Fiorino , Beatrice Severino
DOI: 10.1016/S0968-0896(02)00091-3
关键词: Benzopyran 、 Potassium channel 、 Lactam 、 Chemical synthesis 、 Adapter molecule crk 、 Stereochemistry 、 Chemistry 、 Smooth muscle 、 Bicyclic molecule 、 Cromakalim
摘要: As part of a search for new potassium channel openers, the synthesis and vasorelaxant activity 1,4-benzoxazine derivatives derived from transformation benzopyran skeleton cromakalim were described. Several provided with significant an overall pharmacological behavior similar to CRK (1f, 1i, 2d, 2e, 2f 2i).
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