β-Lactams from Fischer Carbene Complexes: Scope, Limitations, and Reaction Mechanism
作者： Israel Fernández , Miguel A. Sierra
DOI: 10.1007/7081_2012_87
关键词: Chemistry 、 Yield (chemistry) 、 Combinatorial chemistry 、 Photochemistry 、 Reaction mechanism 、 Ligand 、 Imine 、 Nucleophile 、 β lactams 、 Transition metal carbene complex 、 Scope (project management)
摘要: The irradiation (visible light) of Fischer carbene complexes promotes the reversible insertion a cis-carbonyl ligand into metal–carbene carbon bond in process known as photocarbonylation. This reaction gives rise to formation ketene-like which are able react with nucleophiles yield great variety products. When nucleophile is an imine, β-lactams formed good excellent yields and high diastereoselectivities. scope limitations this synthetically useful transformation well its mechanism considered herein.
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