Diffuse Intrinsic Pontine Glioma: New Pathophysiological Insights and Emerging Therapeutic Targets
作者： Tessa Johung , Michelle Monje
DOI: 10.2174/1570159X14666160509123229
关键词: Neuroscience 、 Epigenomics 、 Brain Stem Neoplasm 、 Median survival 、 Disease mechanisms 、 Glioma 、 Rapid autopsy 、 Medicine
摘要: Background Diffuse Intrinsic Pontine Glioma (DIPG) is the leading cause of brain tumor-related death in children, with median survival less than one year. Despite decades clinical trials, there has been no improvement prognosis since introduction radiotherapy over thirty years ago. Objective To review features and current treatment challenges DIPG, discuss emerging insights into unique genomic epigenomic mechanisms driving DIPG pathogenesis that present new opportunities for identification therapeutic targets. Conclusion In recent years, an increased availability biopsy rapid autopsy tissue samples preclinical investigation combined advent profiling tools to yield remarkable advancements our understanding disease mechanisms. As well, a deeper developmental context shedding light on targets microenvironment childhood brain.
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