Outcomes of simultaneous resections for patients with synchronous colorectal liver metastases.

作者: A.A.P. Slesser , M. Chand , R. Goldin , G. Brown , P.P. Tekkis

DOI: 10.1016/J.EJSO.2013.09.012

关键词: Survival rateNodal statusColorectal cancerSurgeryMedicineHepatectomyRetrospective cohort studyDisease severityInternal medicineAdverse effectGastroenterologyBlood loss

摘要: Abstract Introduction The aim of this study was to determine the outcomes associated with simultaneous resections compared patients undergoing sequential for synchronous colorectal liver metastases. Method Consecutive hepatic between 2000 and 2012 metastases were identified from a prospectively maintained database. Results Of 112 that performed, 36 76 resections. There no difference in disease severity: number ( P 0.228), metastatic size 0.58), primary tumour nodal status 0.283), CEA 0.387) or presence extra-hepatic 1.0). Major performed 23 (64%) 60 (79%) groups respectively 0.089). Intra-operatively differences found blood loss 1.0), duration surgery 0.284) adverse events post-operative complications 0.161) mortality 0.241). length hospital stay 14 (95% CI 12.0–18.0) 18.5 16.0–23.0) days 0.03). 3-year overall survival 75% 64% 0.379). recurrence free 61% 46% 0.254). Conclusion Simultaneous result similar short-term long-term as receiving comparable are significant reduction stay.

参考文章(30)
Massimo Bellomi, Giuseppe Trifiro, Nicola Fazio, Paolo Della Vigna, Antonio Chiappa, Carlo Corbellini, Emilio Bertani, Bruno Andreoni, Andrew P. Zbar, Giancarlo Pruneri, Masatoshi Makuuchi, Giuseppe Viale, Maria Giulia Zampino, Maria Laura Travaini, Gianmarco Contino, Neoadjuvant Chemotherapy followed by Hepatectomy for Primarily Resectable Colorectal Cancer Liver Metastases Hepato-gastroenterology. ,vol. 56, pp. 829- 834 ,(2009)
Dimitrios Dimitroulis, Nikolaos Nikiteas, Theodore Troupis, Dimitrios Patsouras, Panayiotis Skandalakis, Gregory Kouraklis, Role of surgery in colorectal liver metastases: Too early or too late? World Journal of Gastroenterology. ,vol. 16, pp. 3484- 3490 ,(2010) , 10.3748/WJG.V16.I28.3484
Antoine Brouquet, Melinda M. Mortenson, Jean-Nicolas Vauthey, Miguel A. Rodriguez-Bigas, Michael J. Overman, George J. Chang, Scott Kopetz, Christopher Garrett, Steven A. Curley, Eddie K. Abdalla, Surgical strategies for synchronous colorectal liver metastases in 156 consecutive patients: classic, combined or reverse strategy? Journal of The American College of Surgeons. ,vol. 210, pp. 934- 941 ,(2010) , 10.1016/J.JAMCOLLSURG.2010.02.039
O. Turrini, F. Viret, J. Guiramand, B. Lelong, T. Bège, J.R. Delpero, Strategies for the treatment of synchronous liver metastasis. Ejso. ,vol. 33, pp. 735- 740 ,(2007) , 10.1016/J.EJSO.2007.02.025
A.A.P. Slesser, C. Simillis, R. Goldin, G. Brown, S. Mudan, P.P. Tekkis, A meta-analysis comparing simultaneous versus delayed resections in patients with synchronous colorectal liver metastases Surgical Oncology-oxford. ,vol. 22, pp. 36- 47 ,(2013) , 10.1016/J.SURONC.2012.11.002
Skye C Mayo, Carlo Pulitano, Hugo Marques, Jorge Lamelas, Christopher L Wolfgang, Wassila De Saussure, Michael A Choti, Isabelle Gindrat, Luca Aldrighetti, Eduardo Barrosso, Gilles Mentha, Timothy M Pawlik, None, Surgical Management of Patients with Synchronous Colorectal Liver Metastasis: A Multicenter International Analysis Journal of the American College of Surgeons. ,vol. 216, pp. 707- 716 ,(2013) , 10.1016/J.JAMCOLLSURG.2012.12.029
Heidi K. Chua, Karl Sondenaa, Gregory G. Tsiotos, Dirk R. Larson, Bruce G. Wolff, David M. Nagorney, Concurrent vs. Staged Colectomy and Hepatectomy for Primary Colorectal Cancer With Synchronous Hepatic Metastases Diseases of The Colon & Rectum. ,vol. 47, pp. 1310- 1316 ,(2004) , 10.1007/S10350-004-0586-Z
Lorenzo Capussotti, Luca Vigano’, Alessandro Ferrero, Roberto Lo Tesoriere, Dario Ribero, Roberto Polastri, Timing of Resection of Liver Metastases Synchronous to Colorectal Tumor: Proposal of Prognosis-Based Decisional Model Annals of Surgical Oncology. ,vol. 14, pp. 1143- 1150 ,(2007) , 10.1245/S10434-006-9284-5