Optimization of the Transcranial Magnetic Stimulation Protocol by Defining a Reliable Estimate for Corticospinal Excitability

作者: Koen Cuypers , Herbert Thijs , Raf L. J. Meesen

DOI: 10.1371/JOURNAL.PONE.0086380

关键词: Protocol (science)Motor thresholdAudiologySex factorsStimulationPyramidal tractsSignal amplificationTranscranial magnetic stimulationElectromyographyMedicine

摘要: The goal of this study was to optimize the transcranial magnetic stimulation (TMS) protocol for acquiring a reliable estimate corticospinal excitability (CSE) using single-pulse TMS. Moreover, minimal number stimuli required obtain CSE investigated. In addition, effect two frequently used intensities [110% relative resting motor threshold (rMT) and 120% rMT] gender evaluated. Thirty-six healthy young subjects (18 males 18 females) participated in double-blind crossover procedure. They received 2 blocks 40 consecutive TMS at either 110% rMT or randomized order. Based upon our data, we advise that least 30 are most CSE. Stimulation intensity had no significant influence on estimation. results revealed with higher rMT, fewer were reach stable current findings can be design similar experiments.

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