Investigation of the effect of oxy bridging groups in dinuclear Zn(II) complexes that catalyze the cleavage of a simple phosphate diester RNA analogue.
作者： Mark F. Mohamed , Alexei A. Neverov , R. Stan Brown
DOI: 10.1021/IC9015965
关键词: Cleavage (embryo) 、 Phosphate 、 Acid dissociation constant 、 Medicinal chemistry 、 Potentiometric titration 、 RNA 、 Metal 、 Ligand 、 Chemistry 、 Stereochemistry 、 Catalysis
摘要: Two sets of dinuclear Zn(II) complexes were prepared to determine the effect presence oxyanionic bridging groups between metal centers on catalytic activity toward methanolysis RNA analogue 2-hydroxypropyl-4-nitrophenyl phosphate (HPNPP, 2). The Zn(II)2 bis(di-(2-pyridylmethyl)amino)-m-xylene (6) and 2,6-bis(di-(2-pyridylmethyl)amino)-4-methylphenol (7) compared assess a phenoxide ligand, while complex 1,3-bis-N1-(1,5,9-triazacyclododecyl)-propan-2-ol (8) was 2-propoxy group previously studied 1,3-bis-N1-(1,5,9-triazacyclododecyl)-propane (4). Detailed kinetic studies cleavage 2 including kobs vs [catalyst] plots sspH-rate profiles performed for each system along with potentiometric titration experiments acid dissociation constants catalytically relevant groups. results show that inclusion phenoxy b...
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