A multiplexed hybrid LC-MS/MS pharmacokinetic assay to measure two co-administered monoclonal antibodies in a clinical study
作者： John Lowe , An Song , Surinder Kaur , Keyang Xu , Luna Liu
DOI: 10.4155/BIO.14.142
关键词: Antibody 、 Bioanalysis 、 Peptide 、 Lc ms ms 、 Quantitative proteomics 、 Chromatography 、 Clinical study 、 Pharmacokinetics 、 Chemistry 、 Molecular biology 、 Monoclonal antibody
摘要: … This report represents early evidence on the multiplexing capability of LC–MS/MS on the clinical pharmacokinetic (PK) assessment of co-administered therapeutic mAbs. …
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Michael T. Furlong, Zheng Ouyang, Steven Wu, James Tamura, Timothy Olah, Adrienne Tymiak, Mohammed Jemal, A universal surrogate peptide to enable LC-MS/MS bioanalysis of a diversity of human monoclonal antibody and human Fc-fusion protein drug candidates in pre-clinical animal studies. Biomedical Chromatography. ,vol. 26, pp. 1024- 1032 ,(2012) , 10.1002/BMC.2759
M. Stern, R. Herrmann, Overview of monoclonal antibodies in cancer therapy: present and promise Critical Reviews in Oncology Hematology. ,vol. 54, pp. 11- 29 ,(2005) , 10.1016/J.CRITREVONC.2004.10.011
Fumin Li, Douglas Fast, Steve Michael, Absolute quantitation of protein therapeutics in biological matrices by enzymatic digestion and LC–MS Bioanalysis. ,vol. 3, pp. 2459- 2480 ,(2011) , 10.4155/BIO.11.237
Bruno Domon, Ruedi Aebersold, Options and considerations when selecting a quantitative proteomics strategy Nature Biotechnology. ,vol. 28, pp. 710- 721 ,(2010) , 10.1038/NBT.1661
Irene van den Broek, Wilfried M.A. Niessen, William D. van Dongen, Bioanalytical LC-MS/MS of protein-based biopharmaceuticals Journal of Chromatography B. ,vol. 929, pp. 161- 179 ,(2013) , 10.1016/J.JCHROMB.2013.04.030
Donald S. Kirkpatrick, Scott A. Gerber, Steven P. Gygi, The absolute quantification strategy: a general procedure for the quantification of proteins and post-translational modifications Methods. ,vol. 35, pp. 265- 273 ,(2005) , 10.1016/J.YMETH.2004.08.018
Olivier Heudi, Samuel Barteau, Dieter Zimmer, Joerg Schmidt, Kurt Bill, Natalie Lehmann, Christian Bauer, Olivier Kretz, Towards absolute quantification of therapeutic monoclonal antibody in serum by LC-MS/MS using isotope-labeled antibody standard and protein cleavage isotope dilution mass spectrometry. Analytical Chemistry. ,vol. 80, pp. 4200- 4207 ,(2008) , 10.1021/AC800205S
Carola W.N. Damen, Els R. de Groot, Marianne Heij, David S. Boss, Jan H.M. Schellens, Hilde Rosing, Jos H. Beijnen, Lucien A. Aarden, Development and validation of an enzyme-linked immunosorbent assay for the quantification of trastuzumab in human serum and plasma. Analytical Biochemistry. ,vol. 391, pp. 114- 120 ,(2009) , 10.1016/J.AB.2009.05.030
Hongyan Li, Robert Ortiz, Linh Tran, Michael Hall, Chris Spahr, Ken Walker, John Laudemann, Sterling Miller, Hossein Salimi-Moosavi, Jean W. Lee, General LC-MS/MS Method Approach to Quantify Therapeutic Monoclonal Antibodies Using a Common Whole Antibody Internal Standard with Application to Preclinical Studies Analytical Chemistry. ,vol. 84, pp. 1267- 1273 ,(2012) , 10.1021/AC202792N
Xiaotao Duan, Lipeng Dai, Shang-Chiung Chen, Joseph P. Balthasar, Jun Qu, Nano-scale liquid chromatography/mass spectrometry and on-the-fly orthogonal array optimization for quantification of therapeutic monoclonal antibodies and the application in preclinical analysis Journal of Chromatography A. ,vol. 1251, pp. 63- 73 ,(2012) , 10.1016/J.CHROMA.2012.06.007