Occurrence and function of cyclic nucleotides in blood vessels.

摘要: The literature concerned with studies of the occurrence and function cyclic nucleotides in blood vessels is reviewed. Emphasis placed on critical evaluation evidence which relates to hypothesis that mediate effects drugs neurotransmitters vascular contractility. AMP mediates vasodilation, especially induced by β-adrenergic relaxation, supported many experimental approaches, but it concluded remains unconvincing based criteria established for such a mediator role. Possible sites action are discussed. demonstrated membrane electrophysiology calcium ion pumps reviewed as possible causes relaxation. role both disease, hypertension Finally needs further research this area suggested.