Activation of nucleus accumbens NMDA receptors differentially affects appetitive or aversive taste learning and memory

摘要: Taste memory depends on motivational and post-ingestional consequences; thus, it can be aversive (e.g., conditioned taste aversion, CTA) if a novel, palatable is paired with visceral malaise, or appetitive no intoxication appears after novel consumption, preference developed. The nucleus accumbens (NAc) plays role in hedonic reactivity to stimuli, recent findings suggest that reward aversion are differentially encoded by the activity of NAc neurons. present study examined whether requirement for NMDA receptors core during rewarding learning differs from conditioning, as well retrieval versus memory, using CTA model, respectively. Bilateral infusions (1 μg/μl, 0.5 μl) into were performed before acquisition CTA. Activation training did not alter formation. Furthermore, injections had effect memory; however, 24 h later, extinction was significantly delayed. Also, injections, made familiar retrieval, interrupted development produced delay later. These results formation produces neurochemical changes have differential requirements memory.