Behavioral, neuroendocrine and neurochemical effects of the imidazoline I2 receptor selective ligand BU224 in naive rats and rats exposed to the stress of the forced swim test
作者： David P. Finn , Octavi Martí , Michael S. Harbuz , Astrid Vallès , Xavier Belda
DOI: 10.1007/S00213-003-1392-3
关键词: Imidazoline receptor 、 Endocrinology 、 Hypothalamus 、 Agonist 、 Catecholamine 、 Internal medicine 、 Monoamine neurotransmitter 、 Receptor 、 Chemistry 、 Neurochemical 、 Behavioural despair test
摘要: Rationale There is evidence for alterations in imidazoline2 (I2) receptor density depressed patients. Selective I2 ligands modulate central monoamine levels and activate the hypothalamo-pituitary-adrenal (HPA) axis may have potential as antidepressants.
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