Protein–water displacement distributions
作者： Wolfgang Doster , Marcus Settles
DOI: 10.1016/J.BBAPAP.2005.03.010
关键词: Time domain 、 Analytical chemistry 、 Chemistry 、 Side chain 、 Neutron scattering 、 Protein structure 、 Hydrogen 、 Protein dynamics 、 Molecular physics 、 Displacement (fluid) 、 Anomalous diffusion
摘要: The statistical properties of fast protein-water motions are analyzed by dynamic neutron scattering experiments. Using isotopic exchange, one probes either protein or water hydrogen displacements. A moment analysis the function in time domain yields model-independent information such as time-resolved mean square displacements and Gauss-deviation. From moments, can reconstruct displacement distribution. Hydration displays two dynamical components, related to librational anomalous diffusion along surface. Rotational transitions side chains, particular methyl groups, persist dehydrated solvent-vitrified structure. interaction with induces further continuous on a small scale. Water acts plasticizer displacements, which couple functional processes open-closed ligand exchange.
elsevier.com
sci-hub.se 参考文章(62)
B.N. Brockhouse, N.K. Pope, R.G. Johnson, M. Sakamoto, NEUTRON INELASTIC SCATTERING STUDY OF WATER Journal of the Physical Society of Japan. ,(1962)
Wolfgang Doster, Glass Transition of Hydration Water and Structural Flexibility of Myoglobin Springer, Berlin, Heidelberg. pp. 34- 38 ,(1987) , 10.1007/978-3-642-71705-5_8
F. Parak, E.W. Knapp, D. Kucheida, Protein dynamics Journal of Molecular Biology. ,vol. 161, pp. 177- 194 ,(1982) , 10.1016/0022-2836(82)90285-6
Roger B. Gregory, Protein-solvent interactions Marcel Dekker. ,(1995)
C. Austen Angell, Joe Wong, Glass : structure by spectroscopy M. Dekker. ,(1976)
R. Dixon Phillips, John W. Finley, Protein quality and the effects of processing M. Dekker. ,(1989)
Richard J. Loncharich, Bernard R. Brooks, Temperature dependence of dynamics of hydrated myoglobin. Comparison of force field calculations with neutron scattering data. Journal of Molecular Biology. ,vol. 215, pp. 439- 455 ,(1990) , 10.1016/S0022-2836(05)80363-8
Andrew L. Lee, A. Joshua Wand, Microscopic origins of entropy, heat capacity and the glass transition in proteins Nature. ,vol. 411, pp. 501- 504 ,(2001) , 10.1038/35078119
Mounir Tarek, Glenn J. Martyna, Douglas J. Tobias, Amplitudes and Frequencies of Protein Dynamics: Analysis of Discrepancies between Neutron Scattering and Molecular Dynamics Simulations Journal of the American Chemical Society. ,vol. 122, pp. 10450- 10451 ,(2000) , 10.1021/JA0016506
Marie-Claire Bellissent-Funel, Jean-Marc Zanotti, Sow Hsin Chen, Slow dynamics of water molecules on the surface of a globular protein Faraday Discussions. ,vol. 103, pp. 281- 294 ,(1996) , 10.1039/FD9960300281