The role of self-organization in developmental evolution.

摘要: In developmental and evolutionary biology, particular emphasis has been given to the relationship between transcription factors cognate cis-regulatory elements of their target genes. These constitute gene regulatory networks that control expression are assumed causally determine formation structures body plans. Comparative analysis has, however, established a broad sequence homology among species nonetheless display quite different anatomies. Transgenic experiments have also confirmed many developmentally important are, in fact, functionally interchangeable. Although dependent upon appropriate degree expression, actual construction specific appears not directly linked functions products alone. Instead, self-formation complex patterns, due large part epigenetic non-genetic determinants, remains persisting theme study ontogeny regenerative medicine. Recent evidence indeed points existence self-organizing process, operating through set intrinsic rules forces, which imposes coordination holistic order cells tissue. This repeatedly demonstrated on regeneration as well autonomous vitro. The process cannot be wholly attributed functional outcome protein–protein interactions or concentration gradients diffusible chemicals. phenomenon is examined here along with some methodological theoretical approaches now used understanding causal basis for self-organization development its evolution.