Human neuronal cell line

作者: Gabriele V. Ronnett , Jeffrey S. Nye , Solomon H. Snyder , Lynda D. Hester

DOI:

关键词: Screening methodGlial fibrillary acidic proteinCell biologyNerve growth factorBiochemistryNeurofilamentStainCell cultureBiology

摘要: This invention is directed to continuous, non-maligant, neuronal cell lines, the cells of which: a) in undifferentiated form are essentially free branched process; b) stain positively for neurofilament protein and neurotransmitters; c) do not glial fibrillary acidic protein; d) presence nerve growth factor differentiate into with long processes. Derivative lines such also contemplated. The useful screening methods evaluation chemical biological compounds as well therapeutic uses.

参考文章(1)
G. Ronnett, L. Hester, J. Nye, K Connors, S. Snyder, Human cortical neuronal cell line: establishment from a patient with unilateral megalencephaly Science. ,vol. 248, pp. 603- 605 ,(1990) , 10.1126/SCIENCE.1692158