Effect of ligands that increase cAMP on caerulein-induced zymogen activation in pancreatic acini.
作者： Z. Lu , T. R. Kolodecik , S. Karne , M. Nyce , F. Gorelick
关键词: Pituitary adenylate cyclase-activating peptide 、 Internal medicine 、 Endocrinology 、 Zymogen activation 、 Zymogen 、 Biology 、 Secretin 、 Acinus 、 Acinar cell 、 Ceruletide 、 Vasoactive intestinal peptide
摘要: The pathological activation of proteases within the pancreatic acinar cell is critical to initiating pancreatitis. Stimulation cells with supraphysiological concentrations CCK analog caerulein (CER) leads protease and Agents that sensitize effects might contribute disease. physiological ligands increase cAMP [secretin, VIP, pituitary adenylate cyclase activating peptide (PACAP)] on CER-induced responses were examined in isolated rat acini. Each ligand sensitized zymogen by CER (0.1 nM). VIP PACAP but not secretin also enhanced μM). A cell-permeable activation. antagonist Rp-8-Br-cAMP inhibited these sensitizing effects. These findings suggest levels can CCK-induced
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