Assessment of hepatitis B vaccine-induced seroprotection among children 5-10 years old in Ulaanbaatar, Mongolia.
作者： Erkhembaatar Tudevdorj , Moazzam Ali , Chushi Kuroiwa , Enkhtuya Budbazar , Naryad Sainkhuu
DOI:
关键词: Antibody 、 Hepatitis B virus 、 Hepatitis B vaccine 、 Routine immunization 、 Public health 、 Pediatrics 、 HBsAg 、 Vaccination 、 Medicine
摘要: Summary Hepatitis B virus infection is a serious public health problem. Mongolia one of the countries with highest rates hepatitis in world. The routine immunization vaccine began nationwide 1991. purpose this study was to determine persistence seroprotection (anti-HBs ≥ 10 mlU/mL) children 5-10 years old that were immunized as infants. In total, 438 selected from six facilities Ulaanbaatar through multistage random sampling method. Vaccination information confirmed by checking vaccination records kept facilities. A blood sample obtained each child for anti-HBs, HBsAg and anti-HBc. Of children, five (1.1%) positive 58 (13.2%) anti-HBc positive. Sixty infected excluded total 378 (86.3%) sera evaluated. seroprotective antibodies detected only one-fourth at age ten. Titres anti-HBs decreased significantly (Linear regression p = 0.01). This decrease primarily due rapid living ger areas (p < 0.001) compared apartment 0.152). On other hand, higher socio-economic status had more exposure blood-borne pathogens, probably inappropriate health-seeking behaviors.
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